Like the original, the sequel again manages to be very funny without feeling like it is trying too hard. Sure, the Hank books are crazy madcap whirlwinds as Hank is tossed around by fate, but they mostly (with an exception or two in this book) stay within at least spitting distance of legitimate science fiction (unlike, for example, The Hitchhiker's Guide books).
Hank's world has changed quite a bit as a result of the events of the first book -- corporations have taken over his space station -- but Hank, the overall feel of the book, and the plot structure are not much different. Book 2 has the same kind of humor throughout the book as book 1, and I laughed out loud quite a bit. Thus, people that liked book 1 should like book 2.
A few caveats. First, while generally very similar in feel, this second book is definitely darker in tone than the first. In the first book, Hank seemed more competent and heroic than he gave himself credit for, was highly likable and things turned out very well in the end. In the second book, Hank seems much less competent, and his mistakes get a considerable number of people killed, something he doesn't generally get too upset about. While there is nothing wrong with a second book putting the hero through a bit of a tough time that doesn't fully resolve in the second book, here Hank feels more like a punching bag than a hero at times. The more upbeat feel of the first book felt like a better match with the humor for me. Second, the villain turns out to be something that would fit better into the Hitchhiker's Guide than legitimate science fiction. Third, at least one plot point seems to have been dropped. While these are not entirely trivial points, the overall package is still very likable, entertaining and funny.
P.S. Since the humorous science fiction/fantasy genre is so rare (if we are limiting it to books with a real story) here are some recommendations for others that you might like if you enjoyed the Hank books: (1) John Scalzi's "Agent to the Stars" (alien encounter sci-fi); (2) Jim Bernheimer's "Confessions of a D-List Supervillain" (super-hero fantasy) (3) Lee Doty's "Out of the Black" (urban fantasy set a bit in the future) & (4) Connie Wills' "To Say Nothing of the Dog" (time travel sci-fi, amusing, but not lol funny).